FrusStat> A properly designed and handled large scale RCT will (almost) always be better than a observational study, but the key points are properly designed and handled large scale RCT.
I am more fun of observational studies (also, “properly performed” of course). Even large-scale RCT run out of all variations: do you give medicine early/late, doses, with something else, to what kind of people, etc. Observational studies let you find potential candidates to be confirmed with RCTs.
Back to meta-studies. These quoted sites look a little strange. They may or may not be malicious, but they seem to be a pre-processing step – they automatically include all kind of studies and, seemingly, weight them equally, whether they have 10 or 10000 cases.
I thought Cochrane Review is a gold standard for properly designed meta-studies. could someone find anything on these medicines in Cochrane?