1. The “mitsva” is not to be able to tell the difference between Mordechai and Haman. Some have suggested that falling asleep is the best way to accomplish this.
2. Many have theorized that many Jews are genetically incapable of staying awake while intoxicated, and this is an evolutionary adapation common among all peoples who ancestors were among the first to discover good stuff to drink. Those individuals who spend the day drunk tended to run into things, fall off things or crash into things.
3. If you can drink beer without crashing (so much for the theory of an anti-alcohol gene), and also get sick from grape juice (you mentioned Pesach) that suggests some sort of allergy to grade products, so you might want to talk to a a doctor who can deal with such things.